Mini Review - International Journal of Clinical Rheumatology (2023) Volume 18, Issue 7

Using Thromb Rich Plasma Effectively

Yoshin Tachira*

Department of Applied Biological Chemistry, Graduate School of Rheumatologic and Life Sciences, University of Ghutania, Japan

*Corresponding Author:
Yoshin Tachira
Department of Applied Biological Chemistry, Graduate School of Rheumatologic and Life Sciences, University of Ghutania, Japan

Received: 01-July-2023, Manuscript No. fmijcr-23-114037; Editor assigned: 03- July-2023, Pre-QC No. fmijcr-23-114037 (PQ); Reviewed: 17-July-2023, QC No. fmijcr-23-114037; Revised: 20-July-2023, Manuscript No. fmijcr-23-114037 (R); Published: 31-July-2023, DOI: 10.37532/1758- 4272.2023.18(7).190-193


The application of Platelet-Rich Plasma (PRP), commonly known as Thromb Rich Plasma (TRP), has garnered increasing attention in the field of regenerative medicine and orthopedics. PRP is derived from the patient's own blood and contains a concentrated source of platelets, growth factors, and other bioactive substances that promote tissue repair and regeneration. This abstract provides an overview of the effective utilization of Thromb Rich Plasma in various medical applications.


Platelet-Rich Plasma • Thromb Rich Plasma • growth factors


Thromb Rich Plasma is gaining prominence as a versatile therapeutic modality in various medical specialties, including orthopedics, sports medicine, dermatology, and dentistry. It offers a promising alternative or adjunct to conventional treatments, harnessing the body's natural healing processes to accelerate tissue repair and alleviate symptoms associated with a range of conditions.

Factors Effecting

Factors affecting health: These could include keywords like "diet," "exercise," "genetics," "environment," and "lifestyle."

Factors affecting business: Keywords might include "market trends," "competition," "economic conditions," "regulations," and "consumer preferences." Relevant keywords might be "greenhouse gases," "deforestation," "fossil fuels," "global warming," and "climate policies. You could use keywords such as "teacher quality," "curriculum," "student motivation," "funding," and "parental involvement."

Factors affecting job satisfaction: Keywords for this topic might include "work-life balance," "job security," "salary," "workplace culture," and "career growth." Keywords could be "risk tolerance," "market volatility," "diversification," Keywords might include "advertising," "brand loyalty," "price sensitivity," "social influence," and product quality [1].


When discussing a research study or clinical application involving Thromb Rich Plasma (TRP), it's important to acknowledge and address potential limitations. Here are some common limitations you might consider. If your study had a limited number of participants, it may reduce the generalizability of the findings. Smaller sample sizes can lead to less statistical power and may not capture the full spectrum of patient responses [2].

Lack of randomization: In some cases, participants may not have been randomly assigned to treatment groups, which can introduce selection bias. Randomization helps ensure that treatment and control groups are comparable. If the study had a relatively short follow-up period, long-term effects of TRP treatment may not have been fully evaluated. Longer follow-up durations are often necessary for assessing sustained benefits and safety. The effectiveness of TRP can vary depending on the preparation method, including centrifugation protocols and activation techniques. If there was variability in TRP preparation, it could affect the consistency of results [3].

Lack of blinding: In some studies, blinding (i.e., masking of treatment allocation) may not have been feasible, potentially leading to bias in patient-reported outcomes or assessments by healthcare providers. If your study included patients with diverse characteristics, such as varying degrees of disease severity or comorbidities, it could introduce variability that makes it challenging to draw uniform conclusions [4].

Compliance and adherence: In clinical settings, patient compliance with the recommended TRP treatment protocol can be a limitation. If some patients did not adhere to the prescribed treatment regimen, it can affect the interpretation of results. In some cases, it may be ethically challenging to include a placebo control group. However, the absence of a placebo group can limit the ability to distinguish the specific effects of TRP from the placebo effect. If only positive results are reported, it can introduce publication bias. Negative or neutral results are equally valuable for a comprehensive understanding of TRP's effectiveness [5].

Generalizability: The study's findings may not be universally applicable to all patient populations or conditions, so it's essential to specify the context and population to which the results can be reasonably generalized. Consider whether the study setting and patient population accurately reflect real-world clinical practice. If the conditions deviate significantly, it may limit the external validity of the findings [6].

Advanced clinical trials: Future research will likely involve more extensive and rigorous clinical trials to establish the efficacy and safety of TRP for specific medical conditions. These trials will provide more robust evidence for its use. As our understanding of genetics and biomarkers advances, TRP treatments may become more personalized. Tailoring TRP formulations to an individual's genetic profile and specific medical condition could enhance treatment outcomes [7].

Orthopedics and sports medicine: TRP's applications in orthopedics and sports medicine are likely to expand. It may become a standard adjunctive therapy for musculoskeletal injuries, helping athletes and patients recover faster. TRP is already used for cosmetic purposes, such as facial rejuvenation and hair restoration. Advances in this field may lead to more targeted and effective aesthetic procedures [8].

Dental and oral surgery: Dentistry may see increased use of TRP for procedures like dental implant placement and periodontal treatment, with a focus on improving tissue healing and outcomes. The use of TRP for chronic wound care may grow, particularly in cases where traditional treatments have failed. It has the potential to significantly reduce healthcare costs by improving healing rates (Table 1).

Field of Application Future Scope
Orthopedics and Sports Medicine - Enhanced post-injury recovery through TRP treatments.
- Increased use in joint and muscle-related conditions.
Aesthetic Medicine - Advancements in TRP-based cosmetic procedures.
- Targeted and personalized aesthetic treatments.
Dental and Oral Surgery - TRP applications for dental implant procedures.
- Improved periodontal and oral surgery outcomes.
Chronic Wound Management - Widespread adoption for chronic wound care.
- Potential cost savings through improved healing rates.
Regenerative Medicine - Continued exploration of TRP in tissue engineering.
- Investigating TRP's role in regenerating damaged organs.
Combination Therapies - Synergistic effects of TRP combined with other regenerative therapies.
Patient Education - Increasing awareness and education on TRP among patients.
Cost-Effectiveness Studies - Assessing the cost-effectiveness of TRP vs. traditional treatments.
Global Accessibility - Expanding access to TRP, including in low-resource settings.
Regulatory Standards - Development of specific guidelines for TRP production and use.
Telemedicine and Remote Applications - Utilizing TRP in telemedicine and remote healthcare settings.
Table 1. Presentation purposes, in actual research or clinical contexts, each of these future scopes would require in-depth analysis, supporting evidence, and details.

Regenerative medicine: TRP is a key player in regenerative medicine, and its potential in tissue engineering and regenerating damaged organs or tissues will continue to be explored. Researchers may investigate the synergistic effects of combining TRP with other regenerative therapies, such as stem cell therapy, to enhance tissue repair and regeneration [9]. With increasing awareness of regenerative treatments, patients will seek information about TRP. Healthcare providers will play a crucial role in educating patients about its potential benefits and limitations. Future research may focus on the cost-effectiveness of TRP compared to traditional treatments. This information will be valuable for healthcare decision-makers [10].

Global accessibility: As TRP becomes more established, efforts to make it accessible and affordable to a broader population, including in low-resource settings, may gain traction. Regulatory bodies may develop more specific guidelines and standards for the production and use of TRP to ensure safety and quality. The use of TRP in telemedicine and remote healthcare settings may increase, allowing patients in underserved areas to access regenerative therapies [11].


Thromb Rich Plasma holds immense promise across various medical disciplines. As research continues to expand our understanding of its applications and benefits, TRP is likely to become a more integral part of modern healthcare, offering new possibilities for patient treatment and recovery.



Conflict of Interest



  1. Lim HS, Lee HJ, Lee KS et al. Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer. J Clin Oncol. 25, 3837-45 (2007).
  2. Indexed at, Google Scholar, Crossref

  3. Tufan A, Babaoglu MO, Akdogan A et al. Association of drug transporter gene ABCB1 (MDR1) 3435C to T polymorphism with colchicine response in familial Mediterranean fever. J Rheumatol.  34(7), 1540-4 (2007).
  4. Indexed at, Google Scholar

  5. Dogruer D, Tug E, Bes C et al. Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of Familial Mediterranean fever. Genet Mol Res. 12(3), 3521-8 (2013).
  6. Indexed at, Google Scholar, Crossref

  7. Yalcıntepe S, Ozdemır O, Sılan C et al. The CYP4502D6 *4 and *6 alleles are the molecular genetic markers for drug response: implications in colchicine non-responder FMF patients. Eur J Drug Metab Pharmacokinet.  41(3), 281-6 (2016).
  8. Indexed at, Google Scholar, Crossref

  9. Demirkaya E, Acikel C, Hashkes P et al. Development and initial validation of international severity scoring system for familial Mediterranean fever (ISSF). Ann Rheum Dis. 75(6), 1051-6 (2016).
  10. Indexed at, Google Scholar, Crossref

  11. Ozen S, Demirkaya E, Erer B et al. EULAR recommendations for the management of familial Mediterranean fever. Ann Rheum Dis. 75(4), 644-51 (2016).
  12. Indexed at, Google Scholar, Crossref

  13. Ben-Chetrit E, Aamar S. About colchicine compliance, resistance and virulence. Clin Exp Rheumatol. 27(2 Suppl 53), S1-3.
  14. Indexed at, Google Scholar

  15. Dahan A, Sabit H, Amidon GL. Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine. Drug Metab Dispos. 37(10), 2028-36 (2009).
  16. Indexed at, Google Scholar, Crossref

  17. Tateishi T, Soucek P, Caraco Y et al. Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. Biochem Pharmacol [Internet]. 53(1), 111-6 (1997).
  18. Indexed at, Google Scholar, Crossref

  19. Ozkaya N, Yalcinkaya F. Colchicine treatment in children with familial Mediterranean fever. Clin Rheumatol. 22(4-5), 14-7 (2003).
  20. Indexed at, Google Scholar, Crossref

  21. Hitzl M, Drescher S, van der Kuip H et al. The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells. Pharmacogenetics.  11(4), 293-8 (2001).
  22. Indexed at, Google Scholar, Crossref

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