In children and adolescents with Multisystem Inflammatory Syndrome in Children (MISC): the significance of brain and heart imaging

Author(s): Emir Acarbay

Multisystem Inflammatory Syndrome in Children (MIS-C), which was recently discovered in a small number of SARS-CoV-2-infected children, is similar to Kawasaki disease (KD), an unidentified medium vessel vacuity. 68% of patients with MIS-C will require admission to the intensive care unit, in contrast to acute COVID-19 infection, which is typically mild in children. Myocarditis and coronary artery ectasia/aneurysm are among the most common cardiovascular complications in MIS-C; consequently, close clinical evaluation is required at diagnosis and during follow-up. Echocardiography is the foundation methodology for myocardial capability and coronary supply route assessment in the intense stage. During convalescence and in adolescents, where echocardiography may not provide adequate images, cardiovascular magnetic resonance (CMR) detects diffuse myocardial inflammation, including oedema and fibrosis, myocardial perfusion, and coronary artery anatomy. MIS-C involves the brain less frequently than cardiovascular disease does. However, given that we do not yet know how it affects brain development, it is not uncommon and should be monitored through clinical evaluation and brain magnetic resonance imaging (MRI). T2- hyperintense lesions with restricted diffusion and bilateral thalamic lesions are seen on the MIS-C brain MRI. To finish up, MIS-C is a multisystem infection influencing numerous essential organs, like heart and cerebrum. Physicians will be able to prevent the terrible complications of MIS-C with the assistance of clinical awareness, the utilization of cuttingedge, high-tech imaging modalities, and cutting-edge treatment protocols that include medication for support and anti-inflammatory purposes.