Human ocular surface in microcirculation by assisted video microscopy

Author(s): Alexander Franceschini

Anterior segment features of the eye may now be accurately measured using non-invasive imaging methods [1]. In this work, the ocular surface of healthy adults is subjected to the innovative oxygen delivery index concept, which measures microvascular capacity for oxygen transport [2]. The goal of the study was to evaluate the technologies that were utilised to collect data from the human ocular surface [3]. In order to determine if the ODIN concept has the necessary sensitivity to identify and distinguish between microvascular structure and function in limbal and bulbar conjunctiva, we also conducted this validation [4]. Twenty healthy participants had their limbal and bulbar conjunctiva measured many times using computer-assisted video microscopy and diffuse reflectance spectroscopy [5]. Functional capillary density, capillary flow velocity, and microvascular oxygen saturation were the three metrics that were retrieved during the analysis. Compared to bulbar conjunctiva, the limbus has higher capillary density and oxygen extraction, which may be detected with appropriate sensitivity [6]. Examining the ocular surface is simple, and imaging methods looking at the anterior ocular vascular networks are increasingly being employed to identify morphological vessel patterns linked to disease [7].