Abstract

Cardiac Tamponade and Intermittent Pancytopenia With a rare case of Addison's disease

Author(s): Richard Femin

To describe the first instance of intermittent pancytopenia and cardiac tamponade coexisting with autoimmune Addison's disease to our knowledge. A year-old woman attended on three separate occasions with a variety of symptoms. Her assessment revealed substantial pericardial effusion with cardiac tamponade and occasional pancytopenia white blood cell, haemoglobin, and platelets. The diagnosis of primary adrenal insufficiency brought about by AAD was confirmed by additional research, which included a morning blood cortisol level of 1027, an adrenocorticotropic hormone level of 1027, and positive 21-hydroxylase antibodies. Steroid therapy led to an immediate improvement in hemodynamic and normalisation of all blood cell lines. Diagnosis of AAD is frequently postponed or ignored. The most likely causes of pancytopenia in AAD are either marrow suppression during an acute illness, which is aggravated by hypoadrenalism, or perhaps a marrow response mediated by the autoimmune system. It has been reported that AAD can develop pericarditis and cardiac tamponade when polyglandular autoimmune syndrome type II is present [1]. The pericardium is autoimmune ally inflamed in the pathophysiology, which results in an initial inflammatory response and fast fluid buildup. Conclusion: Rare signs of an Addison Ian crisis include intermittent neutropenia and pericarditis with cardiac tamponade [2]. The most frequent cause of primary adrenal insufficiency in industrialised nations is autoimmune Addison's disease, which can manifest itself in a variety of ways. We provide a case of a patient who showed signs of AAD in the form of cardiac tamponade and neutropenia [3]. According to our understanding, this is the first instance in which these two companies have been linked to AAD [4].