A multiparametric MRI score for prostate cancer detection: Performance in patients with and without endorectal coil

Author(s): Roberta Fusco,Antonella Petrillo, Sergio V Setola, Vincenza Granata, Nicola Raiano, Paola Delprete, Giuseppe Quarto, Alessandro Izzo Sisto Perdona

Purpose: To assess the diagnostic performance of multiparametric MRI (mpMRI), in the detection of prostate cancer in two different coil setting: endorectal coil (ERC) versus phased array coil alone (PAC). Materials and Methods: The study included 302 out of 395 consecutive patients with PSA values between 2.5-4 ng/ml and an abnormal Digital Rectal Examination (DRE), or patients with PSA values between 4-10ng/ml, independently from DRE. Each patient provided informed consent to undergo at serum free/total PSA ratio (f/t PSA) assay, morphological MRI (mMRI), DWI, MRS, and Trans Rectal Ultrasonography (TRUS) biopsy. The MRI data sets were scored singularly and then mMRI, DWI and MRS data were combined in a single score (cMRI score). cMRI score was correlated to negative biopsies and Gleason score biopsies. ROC curve and McNemar tests were performed. Results: cMRI score showed high value of sensitivity and NPV for both coil setting (84% and 93% respectively using ERC, 87% and 87% respectively using PAC). cMRI score using ERC did not show statistical superiority compared with cMRI score using PAC alone (p value at McNemar test > 0.05). A significant correlation was obtained comparing the cMRI score to the Gleason score for both coil conditions. Conclusions: Pelvic phased array coil imaging of the prostate produces high quality images and the overall performance in prostate cancer detection is equal than those obtained with endorectal coil imaging.

New slither io game source: https://www.openaccessjournals.com/admin/author-interviews/slitherio/