Annals of Clinical Trials and Vaccines Research

Xenobiotic Metabolism Scholarly Journal

 Xenobiotic metabolism covers the biochemical modification of drugs and xenobiotics by living organisms.These biotransformations are usually carried out by specialized enzymatic systems such as the cytochrome P450s and the UDP-glucuronosyltransferases,with the aim to make compounds more soluble and more easily excreted from the body. Understanding how xenobiotic metabolism occurs in the human body is important in two fields particularly: drug discovery and toxicology. In drug discovery, one needs to understand what metabolites of a potential drug are formed to be able to study what effects they have. Occasionally, some metabolites are more potent than the drug itself. For example, cyclophosphamide is a prod rug that is implicated to be activated by P450s  . Furthermore, metabolism can cause unwanted side effects, for example by interfering with the potential use of other drugs by inhibiting certain enzymes and, for example, change blood concentrations of drugs  [4]. In the field of toxicology, understanding the metabolism of all types of chemicals is important, even if the compounds themselves are not toxic, and it is their metabolites that cause the toxic effects. This also makes it important to understand metabolism when building in silico models that predict toxicity, as the molecular properties of the original compound and its metabolites may differ significantly. The evaluation of the metabolic fate and metabolism similarity of target and analog compounds in the context of read-across is an essential part of the framework for toxicological assessment proposed by Wu et al.Aand relevant methods and tools are emphasized in a recent review on in-silico approaches for predicting toxicity.

High Impact List of Articles

Relevant Topics in General Science