Journal of Labor and Childbirth

Whole-genome Sequencing Research Articles

Whole-genome sequencing (WGS) is a systematic approach to the study of whole genomes. Genomic knowledge was instrumental in defining genetic diseases, characterizing mutations that cause the progression of cancer, and monitoring outbreaks of disease. Rapidly declining sequencing costs and the ability with today's sequencers to produce vast amounts of data make whole-genome sequencing a powerful resource for genomics research. Genetic mutation is a permanent change in DNA. Mutations may or should not bring about changes in the organism. Although this approach is widely associated with human genome sequencing, the versatile, modular nature of next-generation sequencing (NGS) technology makes it equally useful for the sequencing of any species of agricultural interest, such as livestock, plants or disease-related microbes. Apart from focused approaches such as exome sequencing or targeted resequencing, which analyzes a limited portion of the genetic code, thought the entire-genome sequencing gives an objective knowledge of the overall genome. It is ideal for applications for discovery, such as identifying causative variants and assembling novel genomes. Whole-genome sequencing can detect variants of single nucleotides, insertions/deletions, and changes in the number of copies.

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