ISSN: 2048-9145

Pharmaceutical Bioprocessing

Use Of Proteomics-in Drug-Designing

Proteomics is a forum for science which is gaining widespread use in drug discovery and drug development programmes. Defined as the genome 's protein complement, the proteome is a varied and complex molecular repertoire that in many ways determines the genome 's functional shape. Proteomics 'importance is a direct consequence of proteins' central role in establishing the biological phenotype of organisms in healthy and diseased states. In addition, proteins form the overwhelming majority of drug targets against which pharmaceutical drug design processes are initiated. Proteomics contributes important insights that can be used to determine the pathophysiological basis of the disease and to study the mechanistic basis for drug action and toxicity by studying the interrelationships between proteins that occur in health and disease and after drug treatment. Proteomics is also an effective means of identifying biomarkers with the potential to improve decision-making on drug efficacy and safety issues based on data derived from key tissue study and biomarker discovery and appropriate use.    

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