Transmitted Drug Resistance
Anti retroviral therapy has led to a dramatic improvement in rates of
morbidity and mortality for people infected with HIV-1. However, the emergence of drug-resistant strains has proved a serious obstacle to achieving successful treatment regimens. especially , the phenomenon of primary or transmitted resistance, when a private is infected by a strain of HIV-1 already immune to one or more drugs, has emerged as a possible threat to the success of antiretroviral therapy.
The increased use of antiretroviral agents in both developed and developing countries has led to a rise within the incidence of drug resistance and subsequently an outsized pool of resistant virus becoming available to determine new infections. Transmission of drug-resistant
viruses occurs regardless of the route of infection. However, when assessing the
epidemiology of primary resistance, one should take care to exclude the likelihood of undisclosed drug exposure, particularly in patients who may have lived in additional than one country and for whom previous medical records could also be unavailable for consultation.
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