ISSN: 1758-4272

International Journal of Clinical Rheumatology

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 The liver is the largest solid organ, the largest gland and one of the most vital organs that functions as a centre for metabolism of nutrients and excretion of waste metabolites. Its primary function is to control the flow and safety of substances absorbed from the digestive system before distribution of these substances to the systemic circulatory system. A total loss of liver function could leads to death within minutes, demonstrating the liver‘s great importance, in view of this, this study was undertaken to review the physiology of the liver with a view to keep it functioning at its optimum and maintaining good health so as to avoid liver damages such as fatty liver, liver fibrosis and cirrhosis. The cells that will eventually make up the adult liver originated during embryogenesis from the ventral foregut definitive endoderm. The different developmental stages of the liver involves establishment of competence for liver formation, after which liver specification, hepatic bud formation, growth and finally differentiation will occur. During the development of the liver, as well as certain duration after partus, the metabolic profile of the young liver is far from that of the adult phenotype. Prior to birth, and shortly thereafter, many metabolic changes occur in the liver.  

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