ISSN: 2048-9145

Pharmaceutical Bioprocessing

Strain Selection And Improvement Innovations

 In industry, genetic manipulations are used to obtain strains that produce hundreds or thousands of times more than the ones produced by the isolated strain originally. Traditionally, these strain improvement systems employ mutagenesis accompanied by scanning or selection; this is called brute force technology. Microbial strains are routinely obtained by mutagenesis and random screening and/or selection which overproduce commercially important metabolites. Advances in recombinant DNA technology have allowed improved microbial strains to be engineered by unique addition or deletion of certain genes. The key to the genetic engineering approach, however, is the identification of genes controlling metabolite production.  

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