Journal of Diabetes Medication & Care

ROMA (Risk Of Malignancy Algorithm) Scholarly Peer-review Journal

The Ovarian Malignancy Algorithm Risk (ROMA) combines the outcomes of HE4, CA125, and menopausal status into a number score. If the patient is premenopausal then a ROMA score of less than 1.14 is associated with a low risk of having a surgical malignancy. If the patient is postmenopausal then a ROMA score of less than 2.99 is consistent with a low probability of finding a surgical malignancy. ROMA is intended as an help in the evaluation of whether a premenopausal or postmenopausal woman presenting with an ovarian adnexal mass has a high or low risk of having surgical malignancy. For women who meet the following requirements, ROMA is indicated: over 18 years of age; ovarian adnexal mass present for which surgery is scheduled and who have not yet referred to an oncologist. ROMA must be interpreted alongside an independent clinical and radiological evaluation. ROMA is not intended to be a screening or an independent or tumor-monitoring assay. Tumor monitoring should be ordered separately, using HE4 and/or CA125.    

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