Annals of Clinical Trials and Vaccines Research

Polyomavirus-Associated Nephropathy

  Polyomavirus-associated nephropathy (PVAN) is one of the most common viral complications in renal transplant recipients and is an increasingly recognized cause of renal transplant dysfunction and graft loss. Since the first description of PVAN in 1995, an increasing prevalence rate from 1% to 10% has been evidenced. The increase in prevalence data could be due to the introduction of new deeply immunosuppressive drugs and/or the relative decline in acute rejection rates. PVAN can lead to kidney graft loss in 10% up to 100% of the cases, determining the return in hemodialysis within 6 to 60 mo, thus significantly and markedly reducing the graft survival.  

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