Journal of Biochemistry Research

Migraine Psychosis

 During a 17 year period a 69 year old man had four episodes of psychosis lasting 7-28 days with longstanding migraine with aura . During attacks he had formed hallucination and delusions, including reduplicative paramnesia. His mother was similarly affected. His EEG showed symmetrical frontal delta waves. The time course and EEG changes are almost like acute confusional migraine. The reduplicative paramnesia suggests a focal non-dominant hemisphere dysfunction. Reversible cerebral vasoconstriction syndrome (RCVS) may be a syndrome characterized by reversible segmental cerebral vasoconstriction and severe headache that begins suddenly and with intense pain (ie, a thunderclap headache) with or without neurological symptoms.1,2 Headache is that the main symptom and it peaks in but 1 minute and typically lasts 1 to three hours. 3–5 Neurological symptoms are often transient or persistent; bleeding , ischemia, and brain edema are possible complications. Although the long-term prognosis depends on the existence of those complications, many patients recover without major disabilities.2 Although the pathophysiology remains unknown, a disturbance within the control of cerebral vascular tone seems to be related. within the course of RCVS, repeated cerebral angiography of a couple of weeks to a couple of months shows diffuse and segmental cerebral vasoconstriction followed by the normalization of cerebral arteries.  

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