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chemistry and analysis is critical, 1st to spot the "triage" compounds that don't offer series displaying appropriate SAR and chemical characteristics related to long-run potential for development, then to boost remaining hit series with relevancy the required primary activity, likewise as secondary activities and physiochemical properties specified the agent are helpful once administered in real patients. during this regard, chemical modifications will improve the popularity and binding geometries (pharmacophores) of the candidate compounds, and then their affinities for his or her targets, likewise as up the
chemistry properties of the molecule that underlie necessary. pharmacokinetic/pharmacodynamic (PK/PD), and pharmacological medicine profiles (stability toward metabolic degradation, lack of geno-, hepatic, and internal organ toxicities, etc.) specified the matter or life is appropriate for introduction into animal and human studies. Where as variety of approaches toward the identification and development of hits exist, the foremost eminent techniques area unit supported chemical and biological intuition developed in team environments through years of rigorous apply aimed only at discovering new therapeutic agents.
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