Human Genome Review Articles:
The
genome is the complex of the genetic
information of a cell and in eukaryote (and thus in humans) is stored in the nucleus and mitochondria. While mitochondrial DNA (mt DNA) sequence has been known since 1981, the draft sequence of the nuclear human
genome was first published in February 2001. The last human reference
genome GRCh38/hg38 was released in December 2013 by the
Genome Reference Consortium (GRC) and is the most comprehensive and highest quality mosaic haploid representation compared to previous reference assembly versions, addressing issues about gaps, variants and component and tiling path errors; in addition, for the frst time, it contains sequence-based representations for centromeres and telomeres. Te incontrovertible fact that very long
molecules of human DNA are often contained, following accurate and multiple rounds of folding, within the very limited space of the nucleus, has always attracted attention. In 1990 when
sequencing of human
genome was just at its beginning, geneticist Jérôme Lejeune afrmed that “we have gotten 2 meters of so to talk mag tape in which everything is coded” (Louisiana Legislature, House Committee on the
Administration of Criminal Justice, June 7, 1990). Traditionally, it has actually roughly been estimated over the last decades that the total length of human diploid DNA is around 2 m. The base composition is typically specified quoting the share of guanine (G) and cytosine (C) of a DNA molecule, or GC content and was first estimated through the buoyant density centrifugation
High Impact List of Articles
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Prevalence of elevated lipoprotein(a) levels in Korean: A large population-based study
Rihwa Choi, Mi-Jung Park, Youngju Oh, Sukjung Lee, Sung Ho Kim, Sang Gon Lee, and Eun Hee Lee
Short Communication: Clinical Investigation
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Prevalence of elevated lipoprotein(a) levels in Korean: A large population-based study
Rihwa Choi, Mi-Jung Park, Youngju Oh, Sukjung Lee, Sung Ho Kim, Sang Gon Lee, and Eun Hee Lee
Short Communication: Clinical Investigation
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Predictive value of q waves in inferior leads for the diagnosis of old inferior wall myocardial infarction
Zameer Abedin, Jennifer Dochee, David Gough, Moeen Abedin, Tariq Siddiqi, Debabrata Mukherjee, Zuber D Mulla, Zainul Abedin
Research Article: Clinical Investigation
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Predictive value of q waves in inferior leads for the diagnosis of old inferior wall myocardial infarction
Zameer Abedin, Jennifer Dochee, David Gough, Moeen Abedin, Tariq Siddiqi, Debabrata Mukherjee, Zuber D Mulla, Zainul Abedin
Research Article: Clinical Investigation
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Two decades testing interventions in transgenic mouse models of Alzheimers disease: designing and interpreting studies for clinical trial success
Kieren Egan, & Malcolm Macleod
Clinical Trail Methodology: Clinical Investigation
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Two decades testing interventions in transgenic mouse models of Alzheimers disease: designing and interpreting studies for clinical trial success
Kieren Egan, & Malcolm Macleod
Clinical Trail Methodology: Clinical Investigation
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Vinflunine for the treatment of metastatic transitional cell carcinoma: recent evidence from clinical trials and observational studies
Camille Serrate, Damien Pouessel, Helene Gauthier, Christine le Maignan, Luis Teixeira & Stephane Culine
Review: Clinical Trail Outcomes: Clinical Investigation
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Vinflunine for the treatment of metastatic transitional cell carcinoma: recent evidence from clinical trials and observational studies
Camille Serrate, Damien Pouessel, Helene Gauthier, Christine le Maignan, Luis Teixeira & Stephane Culine
Review: Clinical Trail Outcomes: Clinical Investigation
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Inhaled corticosteroids: the last 5 years
Hengameh H Raissy, H William Kelly
Review: Clinical Trail Outcomes: Clinical Investigation
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Inhaled corticosteroids: the last 5 years
Hengameh H Raissy, H William Kelly
Review: Clinical Trail Outcomes: Clinical Investigation
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Considerations in the design of clinical trials for relapsing multiple sclerosis
Richard Nicholas, Tim Friede
Clinical Trail Methodology: Clinical Investigation
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Considerations in the design of clinical trials for relapsing multiple sclerosis
Richard Nicholas, Tim Friede
Clinical Trail Methodology: Clinical Investigation
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Low-dose enteric-coated aspirin does not inhibit thromboxane B2 and prostaglandin E2: data-derived hypothesis formulation***Low-dose enteric-coated aspirin and platelets
Charles H Hennekens, Scott Hetzel, Michael Pfeffer, Ricky Schneider, Steven Borzak, Wendy Schneider, Victor Serebruany,David DeMets
Research Article: Clinical Investigation
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Low-dose enteric-coated aspirin does not inhibit thromboxane B2 and prostaglandin E2: data-derived hypothesis formulation***Low-dose enteric-coated aspirin and platelets
Charles H Hennekens, Scott Hetzel, Michael Pfeffer, Ricky Schneider, Steven Borzak, Wendy Schneider, Victor Serebruany,David DeMets
Research Article: Clinical Investigation
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New advances in the treatment of Friedreich ataxia: promises and pitfalls
Wolfgang Nachbauer, Sylvia Boesch
Therapeutic Prospective: Clinical Investigation
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New advances in the treatment of Friedreich ataxia: promises and pitfalls
Wolfgang Nachbauer, Sylvia Boesch
Therapeutic Prospective: Clinical Investigation
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