ISSN: 2048-9145

Pharmaceutical Bioprocessing

Embryonic Neural Precursor Cells Scientific Journals

 A highly enriched population of neuroepithelial precursor cells derived from ES cells proliferates within the presence of basic fibroblast protein (bFGF). These cells differentiate into both neurons and glia following withdrawal of bFGF. By further differentiating the cells in serum-containing medium, the neurons express a good sort of neuron-specific genes and generate both excitatory and inhibitory synaptic connections. The expression pattern of position-specific neural markers suggests the presence of a variety of central nervous system (CNS) neuronal cell types. The top journals are peer reviewed scholarly journals. These provide top quality , meticulously reviewed and rapid publication, to cater the insistent need of scientific community.  Upon aggregation to embryoid bodies, differentiating ES cells formed large numbers of neural tube–like structures within the presence of fibroblast protein 2 (FGF-2). Neural precursors within these formations were isolated by selective enzymatic digestion and further purified on the idea of differential adhesion. Following withdrawal of FGF-2, they differentiated into neurons, astrocytes and oligodendrocytes. After transplantation into the neonatal mouse brain, human ES cell–derived neural precursors were incorporated into a spread of brain regions, where they differentiated into both neurons and astrocytes. No teratoma formation was observed in the transplant recipients. These results depict human ES cells as a source of transplantable neural precursors for possible systema nervosum repair.  

High Impact List of Articles

Relevant Topics in Clinical