Journal of Leukaemia & Lymphoma Research

Cystic Fibrosis Open Access Journals

Cystic fibrosis (CF) is a recessive genetic disease in which defects or deficits in cystic fibrosis transmembrane conductance regulator (CFTR) protein result in pancreatic disease phenotypes, sweat glands, and reproductive, respiratory, and digestive systems. Mucociliary clearance is impaired in the lungs of individuals with CF, which promotes chronic polymicrobial infections. Antibiotic treatment and proper disease management have extended the average lifetime of CF patients; however, these polymicrobial lung infections are still the primary cause of morbidity and mortality.Common bacteria that colonize CF lungs over the long term include Pseudomonas aeruginosa, Staphylococcus aureus, Haemophilus influenzae, Burkholderia cepacia complex, Rothia mucilaginosa, and Streptococcus, but each CF individual has a unique microbial community that changes over time (8–10). This highlights the need to characterize microbial communities in each individual CF.

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