Cdk5 Activator
In distinction to traditional cyclin-dependent kinases that area unit vital for mitotic organic process, cyclin-dependent enzyme five (CDK5) is preponderantly activated in post-mitotic
cells and is concerned in varied cellular events. The enzyme activity of CDK5 is tightly regulated by specific activators as well as p35, p39, and cyclin I (CCNI). Here we tend to show that cyclin I-like (CCNI2), a homolog of CCNI, interacts with CDK5 and activates the enzyme activity of CDK5. totally different from CCNI, that colocalizes with CDK5 within the nuclei in transfected cells, CCNI2 principally retains CDK5 within the living substance moreover as on the plasma membrane. what is more, though the expression level of CCNI2 messenger RNA and CCNI2 macromolecule don't modification considerably throughout cell cycle, depletion of CCNI2 with siRNA affects
cell cycle progression moreover as cell proliferation. finally, our knowledge powerfully counsel that CCNI2 could be a novel CDK5 substance and is concerned in
cell cycle regulation.
Cyclin-dependent enzyme five (CDK5) could be a proline-directed serine/threonine enzyme. Despite the high degree of similarity between CDK5 and different typical cyclin-dependent kinases (CDKs) that area unit vital for mitotic organic process, CDK5 sometimes isn't directly concerned in
cell cycle regulation. Instead, it's copiously expressed in post-mitotic
cells like
neurons and is important for neural differentiation1,2,3.
High Impact List of Articles
-
World Gastro 2019: ENDOSCOPIC DIAGNOSIS OF SUSPECTED H. PYLORI INFECTION IN SULAIMANI PEDIATRIC TEACHING HOSPITAL - Heersh HMH Raof Saeed - University of Sulaimani, Iraq
Heersh HMH Raof Saeed
Abstract: Journal of Interventional Nephrology
-
World Gastro 2019: ENDOSCOPIC DIAGNOSIS OF SUSPECTED H. PYLORI INFECTION IN SULAIMANI PEDIATRIC TEACHING HOSPITAL - Heersh HMH Raof Saeed - University of Sulaimani, Iraq
Heersh HMH Raof Saeed
Abstract: Journal of Interventional Nephrology
-
What does the literature tell us about the role of intensive hemodialysis modalities in the management of chronic dialysis-dependent patients?
Robert P. Pauly
Abstract: Journal of Interventional Nephrology
-
What does the literature tell us about the role of intensive hemodialysis modalities in the management of chronic dialysis-dependent patients?
Robert P. Pauly
Abstract: Journal of Interventional Nephrology
-
Complexity of differentiating cerebral-renal salt wasting from SIADH, emerging importance of determining fractional urate excretion
John K. Maesaka
Abstract: Journal of Interventional Nephrology
-
Complexity of differentiating cerebral-renal salt wasting from SIADH, emerging importance of determining fractional urate excretion
John K. Maesaka
Abstract: Journal of Interventional Nephrology
-
Role of PAX1 gene in the occurrence of human neural tube defects: a study in North Indian population
Roumi Deb1, Jyoti Arora, Ratika Samtani, Saraswathy KN and Kalla KA
Short Communication: Research on Chronic Diseases
-
Role of PAX1 gene in the occurrence of human neural tube defects: a study in North Indian population
Roumi Deb1, Jyoti Arora, Ratika Samtani, Saraswathy KN and Kalla KA
Short Communication: Research on Chronic Diseases
-
MicroRNA mediates CD8+ T cell dysfunction in chronic viral infection
Riyasat Ali*
Editorial: Research on Chronic Diseases
-
MicroRNA mediates CD8+ T cell dysfunction in chronic viral infection
Riyasat Ali*
Editorial: Research on Chronic Diseases
Relevant Topics in Medical