Carcinogenesis Open Access Articles
The concept of
cancer “etiology” seems deficient, a minimum of in its classical use within the
pathology of infectious, parasitic, nutrition, metabolic diseases. We examine the application of the terms carcinogenesis,
cancer inducing factors or carcinogenic factors more competent for what happens during
tumor cell conversion, with the mention that the term
carcinogenesis defines the initiation of a tumor, and
oncogenesis its preservation and subsequent evolution.
Tumors develop in those
tissues during which cellular equilibrium has been agitated by hyperplastic, dysplastic or regenerative changes. Clinical and experimental data have proved that in the division process the cell is more accessible to carcinogenic influences than at rest. Human and
veterinary oncology can provide such examples: hyperplastic endometrial and mammary techniques that are referred to hormonal fluctuations represent the standard background for the looks of cancer; bronchial
carcinoma in smokers invariably appears against a dysplastic or metaplasic background of the airways; bone
cancer usually occurs at a young age, when physiological osteogenesis is active. These examples demonstrate that the oncogenic process is more frequent in
tissues with increased cellular activity. The group of primary determining aspects includes: chemical substances; the carcinogenic action of physical agents; and therefore the action of carcinogenic transformation of viruses.
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