ISSN: 2041-6792

Clinical Investigation

Bone Open Access Journals

  PET studies are used on a regular basis in the initial staging of lymphoma patients-pretreatment-and assess response to treatment and prognosis. BM involvement is synonymous of a stage IV and is associated with a worse short and long-term prognosis. Concordant BMu and BM involvement confirmed by a biopsy has been reported to correlate with worse outcomes. The utility of FDG PET-CT in evaluating BM involvement has also been explored by other authors with variable results as to its benefit. Because FDG PET-CT’s are performed routinely now in the pretherapy staging of most lymphoma patients, extracting noninvasively additional information in regards to bone marrow status would be very valuable. Additionally sampling occasionally may not be adequate for pathology interpretation and a repeat procedure becomes challenging. Uncovering quantitative and qualitative parameters to elucidate the etiology of bone marrow uptake may help the radiologist and oncologist.  

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