Case Report - International Journal of Clinical Rheumatology (2022) Volume 17, Issue 2

Tachon's syndrome: Case report and systematic review of the literature

Hamdi Ons*, Sellami Meriem, Miladi Saoussen, Fazaa Alia, Ouenniche Kmar, Souebni Leila, Kassab Selma, Chekili Selma, Ben Abdelghani Kaouther, Laatar Ahmed

Mongi Slim Hospital, Rheumatology, Marsa, Tunisia

*Corresponding Author:
Hamdi Ons
Mongi Slim Hospital, Rheumatology, Marsa, Tunisia

Received: 14-Oct-2021, Manuscript No. fmijcr-21-44662; Editor assigned: 18-Oct-2021, PreQC No. fmijcr-21-44662(PQ); Reviewed: 02-Dec-2021, QC No. fmijcr-21-44662; Revised: 28-Jan-2022, Manuscript No. fmijcr-21-44662(R); Published: 05-Feb-2022, DOI: 10.37532/1758-4272.2022.17(2).032-035


Corticosteroid injections are an interesting therapeutic alternative in rheumatology but are not without adverse effects. We aimed to resume the clinical, diagnostic, and therapeutic characterizations of a rare systemic effect of corticosteroid injections named Tachon’s syndrome (TS). We reported a case of an 80-year-old woman who experienced acute thoracic pain and profuse sweating five minutes after a betamethasone shoulder injection with a normal physical examination. The most common presenting symptoms in the systematic review were chest and back pain as well as sweating. Symptoms mostly occurred suddenly within one to five minutes following corticosteroid injections. Although clinical features are sudden and stressful, the outcome is often excellent. The risk of occurrence is minimal. Diagnosis imposes the exclusion of other medico-surgical emergencies. Patients should be reassured about the benignity of this condition despite its sudden distressing symptoms.


tachon’s syndromecorticosteroid • injections • side effects


Intra-articular corticosteroid injections are one of the most widely used local therapy in rheumatology. This treatment has several general adverse effects that are generally well tolerated [1]. In rare cases, glucocorticoid infiltrations can cause excruciating lumbar, dorsal, and/or thoracic pain. This uncommon entity, known as Tachon’s syndrome (TS), is a tribute to the first rheumatologist who reported this syndrome [2]. Few reports of this complication were found in the literature [2-4]. We reported a case of a female patient who experienced similar symptoms after an intra-articular corticosteroid injection of the shoulder. We also systematically reviewed case reports and case series of TS in order to summarize the clinical and therapeutic characteristics of TS.


The systematic review was performed based on the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) statement recommendation.

Search strategy: We searched the PubMed and Science Direct databases for studies up to 2005 using the search items (“Tachon’s syndrome”) AND (“corticosteroid” OR “glucocorticoid” OR “corticoid”) AND (“side effects” OR “adverse effects”). No restrictions were imposed. We also did manual research on reference lists of retrieved relevant articles.

Study selection: In this review, we included prospective or retrospective descriptive case reports and case series conducted on TS. We excluded papers investigating similar conditions to TS and papers not published in English or French.

Data extraction: The information extracted from the included articles is as follows: Name of the first author, publication year, and number of cases, age, molecule injected, and site of injection, occurrence delay, duration, and type of symptoms.

Case description

An 80-year-old female with no medical history and without known allergies had experienced mechanical pain in her right shoulder for 3 months. On examination, the range of motion of the right shoulder was limited in active mobilization but painfully recovered in passive mobilization. The Jobe and palm-up tests were positive. The remainder of her physical examination was normal.

Radiography of the right shoulder showed moderate degenerative changes in the glenohumeral joint without any calcification or erosion of the adjacent cortex. Ultrasound of the right shoulder joint revealed a rupture of the supraspinatus tendon associated with cleavage of the biceps. Laboratory evaluation included a normal blood count and normal liver and renal function tests. After local anti-inflammatory, analgesic, and functional physiotherapy treatments failed, a local injection of corticosteroid was indicated. After skin disinfection using alcoholic betadine, without local anesthesia, we carried out an injection of 5 mg/ 1 mL of betamethasone suspension (Diprostene®) in a prefilled syringe in the right glenohumeral joint. There was neither a blood test during the pre-injection aspiration, nor resistance during the injection. Five minutes later, the patient experienced acute thoracic pain associated with chest oppression and profuse sweating. There was no lumbar or dorsal pain, nor skin lesions or pruritus. Blood pressure was 110/70 mmHg and heart rate was 97 beats per minute. The blood glucose level from the fingertip was 0.96 g/L. Heart and pulmonary auscultation were normal. An electrocardiograph showed no abnormalities. Chest radiography was unremarkable. Instantly, we elongated the patient with an elevation of the lower limbs. The patient spontaneously improved within 15 minutes with a total resolution of thoracic pain. However, she remained in observation due to persistent fatigue for about an hour. A registration of the case was recorded in the national pharmacovigilance database under the number 407321 on August 14, 2021.

Review of the literature

We reviewed the literature in order to identify cases of TS. We were unable to find extensive reports of this rare syndrome in the literature. Three articles were eligible. Up to 322 cases of TS were reported in the literature (Table 1). The most common presenting symptoms were chest and back pain as well as sweating. Symptoms mostly occurred suddenly within 1 to 5 minutes following corticosteroid injections. Symptoms lasted often less than 15 minutes. Cortivazol was the most provider molecule of TS. Mostly, TS followed injections into the lumbar epidural space. No recurrences were recorded in the studies included.

Authors/ year N Gender Mean Age (years) Molecule Site of injection Occurrence delay Symptoms duration Symptoms
Berthelot et al [2] 2005 318 - - Cortivazol (67%) Hydrocortisone (25%) Betamethasone (7%) Paramethasone acetate (1%) Lumbar epidural (39%) Upper limb (30%) Lower limb (24%) Other locations (7%) 1-5 min (78%) < 1 min (22%) 5-15 min (51%) 1-5 min (31%) > 15 min (15%) < 1 min (3%) Anxiety (87%)
Pain in lumbar region (84%)
Shortness of breath (64%)
Erythema (64%)
Profuse sweating (41%)
Agitation (29%)
Pain in dorsal region (25%)
Transient cough (23%) Abdominal pain (20%)
Transient hypertension (15%)
Paleness (10%)
Hypotension (8%)
Diarrhea (3%)
Headache (3%)
Hajjioui  et al [3]
2 Male 47 Prednisolone acetate Epicondyl 2 min 20 min Back pain
Chest oppression  Erythematous rash of the face
Male 57 Prednisolone acetate Lumbar epidural Instantly 1 hour Back and chest pain
Profuse sweating
Erythematous rash of the face
Rekik     et al [4]
2 Female 64 Cortivazol Shoulder 2-3 min 20 min Low back pain
Chest tightness
Erythematous rash of the face Profuse sweating
Female 43 Cortivazol Lumbar
2-3 min 15 min Sweating
Chest and lumbar pain
Facial erythema

Table 1. Studies assessing Tachon’s syndrome.


Intra-articular corticosteroids can be considered as an additional necessity in the course of treatment of painful and inflamed joints, tendons, and/or ligaments. However, these local treatments may be associated with risks and complications. These risks include sepsis, skin atrophy, tendon rupture, and many other adverse effects [5]. In rare cases, corticosteroid injections may cause unexpected reactions. One of these uncommon complications is TS. The observation presented here can be integrated with this syndrome. There was no other etiology explaining the condition. Symptoms, which consisted of excruciating chest pain and oppression, occurred within five minutes of corticosteroid injection with a spontaneous resolution. According to the French method [6], the partial imputability scores were: C3 for the chronological imputation (score C) and S3 for the semiological imputation (score S). The global imputation (score I) was I4.

TS was first described by the French rheumatologist “Gérard Tachon” who reported his experience with several cases [2]. TS’ occurrence has been estimated to 1 event per 8000 injections or 6.5 years of practice [2]. The rarity of published reports of TS can be explained by the benign nature of this event, its frequent favorable outcome, and maybe its confusion with allergic reactions [2].

Physiopathological mechanisms remain unknown. The allergic mechanism does not seem involved in TS. Indeed, there was no asthma in the medical history of all patients. The urticarial lesions were also rare among patients (2%) as well as recurrence of TS (13%) [3]. However, TS could be explained by the accidental introduction of the product in a vein after its breach occurring during the injection. Other frequent symptoms, such as sweating, pallor, hyper or hypotension, diarrhea, may be related to the involvement of the sympathetic and parasympathetic systems [3]. Furthermore, several authors suggested that TS may be considered as the venous part of Nicolau’s syndrome [7]. Both syndromes are uncommon and cause extreme anxiety to the patient and the physicist. The difference between the two syndromes lies in the fact that the drug substance is injected directly within a blood vessel in Nicolau’s syndrome, causing thus acute arterial thrombosis and livedoid dermatitis. However, in TS, the suspension enters the bloodstream through breaching of a large vein [2]. This explains the delay of symptoms in TS as well as the more frequent occurrence after injections in areas rich in venous plexus [2].

The clinical features of TS may be similar to those observed in transfusion incompatibility reactions [8]. The difference between the conditions remains in the delay of the occurrence of symptoms; TS occurs within one to five minutes following the injection whereas transfusion incompatibility reaction is slower to happen [2]. Several clinical features are likely to occur in TS. However, previous reports showed that lumbar pain was the most frequent symptom (84%) [2]. Berthelot et al. [2] reported that the most frequent site associated with TS was the lumbar epidural injection. However, this side effect was not reported by recent studies [9,10]. Although all molecules of corticosteroids available for intra-articular injections may cause TS, it has been reported that cortivazol was the most frequent molecule associated with TS [2]. The diagnosis of TS remains difficult since symptoms are not specific. It is essential to exclude other conditions that may present with the same symptoms, especially medico-surgical emergencies [4]. TS is usually accompanied by a spectacular procession of symptoms that may alarm the physician and distress the patient. However, it often resolves rapidly and spontaneously. Although none of the 318 French cases of TS experienced any recurrence [2], TS may recur in subsequent injections in 14 – 60% of cases [4].


Although TS is a rare and benign condition, doctors performing corticosteroid injections should be aware of this side effect which imposes the exclusion of other emergencies. Further studies are needed to fully understand the pathogenesis of this condition.


No sources of funding were received in support of this work.

Conflicts of interest



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