Abstract

The Role of Microbiome Alterations in the Pathogenesis of Ankylosing Spondylitis: Insights and Implications for Future Therapies

Author(s): Lucas Martinez*

Ankylosing spondylitis (AS) is a chronic inflammatory disease predominantly affecting the axial skeleton, with an increasing body of evidence suggesting that the gut microbiome plays a critical role in disease onset and progression. This article reviews recent research on the gut microbiome in AS, exploring how dysbiosis and microbial dysregulation may influence immune responses, inflammation, and the development of axial spondyloarthritis. We discuss potential therapeutic strategies targeting the microbiome, including probiotics, prebiotics, and fecal microbiota transplantation, which may offer novel treatment avenues for AS patients. Additionally, the review addresses challenges and future directions in microbiome-based interventions.


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