Abstract

The hidden potential of small synthetic molecules and peptides as affinity ligands for bioseparations

Author(s): Menegatti, Naik and Carbonell

While extensively used as drugs, small synthetic molecules have not yet been widely applied in the industry as affinity ligands for the purification of biopharmaceuticals. Yet, a substantial amount of published research indicates that synthetic ligands, such as triazine scaffolds, amino acids, and peptides show a great deal of promise for becoming the next generation affinity ligands for bioseparations. In this review, we present a comprehensive account on small synthetic ligands, from triazine dyes to the most recent polycyclic peptide ligands, selected for targeting high-value biopharmaceuticals, such as immunoglobulins, blood factors and therapeutic enzymes. These ligands could play a significant role in improving downstream processing and helping the bioprocessing industry overcome the urgent issues of costs and availability posed by growing economies on the global pharmaceutical market.