Successful switching to Infliximab after systemic allergic reaction to Adalimumab drug: a case report

Author(s): Alireza Sadeghi*

Subjective: To describe a case of systemic allergic reaction to Adalimumab drug in an Ankylosing Spondylitis (AS) patient and switching to Infliximab.

Case report: A 43-year-old middleeastern man with a history of AS who was initiated with the treatment of Adalimumab. After the second injection of the drug immediate systemic allergic reaction with the symptoms of dizziness, shortness of the breath, angioedema of the limps and generalized rashes and itching happened.

Discussion: Systemic reactions to Adalimumab although rare have been reported before. In case of allergic reaction to this drug desensitization and switching to another anti-TNFα have been successfully tried.