Abstract

Role of DNA dynamics in Neurodegeneration: New challenges and excitements

Author(s): Jagannatha Rao KS

A dynamic and crucial molecule polymer whose conformation mechanics plays a significant role in biological operates. Recent reports from our science lab indicated the presence of non-BDNA types of conformations in neurodegenerative diseases like Fragile X-syndrome, Huntington's chorea, presenile dementia et al.. Recently, our laboratory discovered the presence of Z-DNA within the hippocampus region of severely affected sickness|Alzheimer's disease|Alzheimer's|Alzheimers|presenile dementia} (AD) brain samples and changed B-conformation in Parkinson disease. The alternate npurine–pyrimidine bases area unit the potential sequences adopting Z-DNA, and this area unit gift within the promoter regions of AD specific genes like amyloid precursor macromolecule (APP), Presenilin and ApoE. The hypothesized Z-DNA is also concerned within the expression of those pathologically necessary genes. In paper, we've a theoretical model on the doable mechanisms/hypothetical proposition of Z-DNA transition and its implications in AD. The developed model we have a tendency to try and perceive that Z-DNA is created within the promoter region of the APP, and Presenilin genes and this conformation could absorb the negative supercoils at that region. There's a decrease within the supercoil density alters the native supercoiling domain and completely regulates organic phenomenon of like APP and Presenilin. we have a tendency to additional try and perceive that Z-DNA is also concerned within the down regulation of genes concerned in Aβ clearance defense mechanisms in AD. The planned model tries to grasp the AD activity pathology like emotions, intake behaviour amnesia, and coordination failure