Abstract

Phyto-formulations for matrix metalloproteinases (mmps): novel targets in uv radiation induced skin carcinoma

Author(s): Swarnlata Saraf

The continuous skin exposure to ultraviolet radiation creates reactive oxygen species leading to photoaging that causes dermal collagen deterioration and elastic fibre degeneration. Such fibers give the skin mechanical energy. In order to maintain the appearance of the skin, a complete understanding of the mechanism behind skin cellular degradation is desired, so that a better cosmetic formulation can be formulated. The studies have been shown that macrophages are crucially involved in skin Carcinoma and express significantly higher levels of M1 (CD40, CD127) and M2 (arginase I) markers as well as higher levels of MMP-9, a pivotal enzyme in cancerous matrix remodeling and cancerous invasion, than macrophages from the basal cell carcinomas. These macrophages represent different receptors like folic acid receptors which was exploited to know the extent of efficacy for delivery of phytoformulations containing nanoparticles, transferosomes, liposomes etc. to cure carcinoma. The flavanoidal rich natural bioactives have been extensively integrated into a suitable base and have proved their ability as topical photoprotectants but their operation has remained constrained due to low solubility profile. Now researchers are working to develop the Novel Targeted formulations to distribute these natural flavanoidal drugs to enhance their potency and eventually skin properties. In current years, the focus area of work is on some traditionally used bioactive moieties as natural matrix metalloproteinases inhibitors (MMPIs) and emphasized on more extensive and specific studies, so that a good combination of natural as well as synthetic MMPIs with the conventional drugs can be used for treating UV radiations induced ailments