Abstract

Novel evidence of the role of oxidative stress, its implication in the evolution of heart failure and atrial fibrillation and possible therapeutic targets. Literature review and meta-analysis

Author(s): Vegim Zhaku, Sheqibe Beadini, Lidija Poposka, Antonio Georgiev

The onset, progression and manifestation of heart failure, atrial fibrillation and other cardiovascular diseases because of the oxidative stress has been recently widely described. Normal equilibrium and homeostasis between specific oxidative pathways and antioxidant production is agitated. An increase of reactive oxygen species such as Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase, Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), myeloperoxidase and other ROS are majorly produced, thus antioxidant capacity and its scavenging properties are decreased. Implication of disturbed ROS/antioxidant balance is the key to understand the pathophysiological effects in the onset, progression and manifestation of cardiovascular diseases. In this review we will discuss about the pathophysiological effect of elevated ROS production in heart failure and atrial fibrillation, describing also therapeutic aspects and options in case of elevated oxidative stress status.