In Female Diabetic Rats, Cerebral Micro Vascular Matrix Metalloproteinase-3 (MMP3) Contributes to Vascular Injury Following a Stroke

Author(s): J Thomas*

Multiparametric Magnetic Resonance Imaging (MRI) has emerged as an essential clinical tool for assessing the severity of focal ischemic stroke, determining treatment goals and forecasting outcomes. While tissue viability in the vicinity of the stroke is the focus of imaging during the acute phase, the evaluation of distributed structural and functional connectivity is the focus of imaging during recovery. Preclinical MRI of experimental stroke models provides a translational platform for the evaluation of potential therapies and validates noninvasive biomarkers in terms of cellular and molecular mechanisms. The transition from acute to chronic imaging, the fundamentals of common MRI techniques used in stroke research, and experimental results obtained by clinical and preclinical imaging to determine tissue viability, vascular remodeling, structural connectivity of major white matter tracts, and functional connectivity using task based and resting state fMRI during the stroke recovery process are all discussed in this brief overview of translational stroke imaging.