Developing an international network for Alzheimers research: the Dominantly Inherited Alzheimer Network

Author(s): John C Morris, Paul S Aisen,Randall J Bateman, Tammie LS Benzinger, Nigel J Cairns,Anne M Fagan, Bernardino Ghetti, Alison M Goate,David M Holtzman, William E Klunk, Eric McDade, Daniel S Marcus,Ralph N Martins6 Colin L Masters, Richard Mayeux,Angela Oliver1 Kimberly Quaid, John M Ringman, Martin N Rossor, Stephen Salloway, Peter R Schofield, Natalie J Selsor,Reisa A Sperling11Michael W Weiner,Chengjie Xiong, Krista L Moulder, Virginia D Buckles

The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of international Alzheimer’s Disease (AD) Centers that are conducting a multifaceted prospective biomarker study in individuals at risk for autosomal dominant AD. The DIAN collects comprehensive information and tissue in accordance with standard protocols from asymptomatic and symptomatic autosomal dominant AD mutation carriers and their noncarrier family members to determine the pathochronology of clinical, cognitive, neuroimaging and fluid biomarkers of AD. This article describes the structure, implementation and underlying principles of the DIAN, as well as the demographic features of the initial DIAN cohort.