Chronic arthropathy in Down’s syndrome: Case report and literature review

Author(s): Mauro A, Zenzeri L, Rega R, Di Nardo G & Sottile R

Down’s Syndrome (DS) is associated with an increased incidence of autoimmune diseases and it association with chronic arthropathyhas been described. This clinical condition has been described as Chronicarthropathy in Down Syndrome (A-DS) since 1984. We report acase of DS and polyarticulararthritis successfully treated with anti-tumor necrosis factor-alfa after immunosuppressant therapy. In this case we emphasize the importance to perform musculoskeletal clinic screening in every patient affected by DS. In fact, a precocious diagnosis of A-DS and an early treatment could prevent future functional limitations especially in this category of patients which present a worse prognosis.

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