Advances in Peptide Synthesis: From Fundamentals to Innovative Strategies

Author(s): Dr. Arjita Khan

Peptide synthesis is a fundamental process in the field of organic chemistry, with significant applications in biochemistry, pharmaceuticals, and biotechnology. This process involves the creation of peptides, which are short chains of amino acids, through the sequential assembly of these building blocks. Peptide synthesis methods have evolved over the years, ranging from classical solid-phase peptide synthesis (SPPS) to modern techniques such as microwave-assisted synthesis, liquid-phase synthesis, and automated peptide synthesizers. The ability to synthesize specific peptides enables the study of their structure, function, and potential therapeutic applications. This abstract provides an overview of the principles, methods, and applications of peptide synthesis, highlighting its importance in advancing our understanding of biological processes and the development of new therapeutic agents. Peptide synthesis, a cornerstone of modern biochemistry and biotechnology, has witnessed significant advancements over the years. This abstract explores the fundamental principles and recent innovative strategies in the synthesis of peptides, which are crucial for the development of various fields such as drug discovery, biomaterials, and molecular biology. We discuss the key techniques, including solid-phase peptide synthesis (SPPS) and liquid-phase methods, highlighting their respective advantages and limitations. Furthermore, we delve into the emerging trends in peptide synthesis, such as automated platforms, novel coupling chemistries, and the incorporation of non-natural amino acids, enabling the creation of peptides with enhanced stability and bioactivity. The synthesis of complex peptides, such as cyclic, stapled, and peptidomimetics, is also explored, underscoring their potential for therapeutic applications. This abstract underscores the critical role of peptide synthesis in pushing the boundaries of molecular science, offering exciting prospects for the development of innovative and potent bioactive compounds.