Annals of Clinical Trials and Vaccines Research

Translational Medicine Open Access

 Translational medicine, also called translational medical science, preclinical research, evidence-based research, or disease-targeted research, area of research that aims to improve human health and longevity by determining the relevance to human disease of novel discoveries in the biological sciences. Translational medicine seeks to coordinate the use of new knowledge in clinical practice and to incorporate clinical observations and questions into scientific hypotheses in the laboratory. Thus, it is a bidirectional concept, encompassing so-called bench-to-bedside factors, which aim to increase the efficiency by which new therapeutic strategies developed through basic research are tested clinically, and bedside-to-bench factors, which provide feedback about the applications of new treatments and how they can be improved. Translational medicine facilitates the characterization of disease processes and the generation of novel hypotheses based on direct human observation. The term translational medicine was introduced in the 1990s but only gained wide usage in the early 2000s. Its definition varies according to the stakeholder. Patients, physicians, and other practitioners tend to use the term to refer to the need to accelerate the incorporation of benefits of research into clinical medicine and to close the gap between “what we know” and “what we practice.” Academics tend to interpret translational medicine as the testing of novel concepts from basic research in clinical situations, which in turn provide opportunity for the identification of new concepts.   

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