Review Journals In Genomics
A
genome is an organism's complete set of DNA, including all of its genes. In contrast to genetics, which refers to the study of individual genes and their roles in inheritance,
genomics aims at the collective characterization and quantification of all of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and
tissues as well as control chemical reactions and carry signals between cells.
Genomics also involves the
sequencing and analysis of genomes through uses of high throughput DNA
sequencing and
bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in
genomics have triggered a revolution in discovery-based research and
systems biology to facilitate understanding of even the most complex biological systems such as the brain. The field also includes studies of intragenomic (within the genome)
phenomena such as epistasis (effect of one
gene on another), pleiotropy (one
gene affecting more than one trait), heterosis (hybrid vigour), and other interactions between loci and alleles within the
genome In addition to his seminal work on the amino acid sequence of insulin, Frederick Sanger and his colleagues played a key role in the development of DNA
sequencing techniques that enabled the establishment of comprehensive
genome sequencing projects. In 1975, he and Alan Coulson published a
sequencing procedure using DNA polymerase with radiolabelled nucleotides that he called the Plus and Minus technique.
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