Research on Chronic Diseases

Pemphigus Vulgaris Scholarly Journals

 Pemphigus vulgaris is a chronic mucocutaneous autoimmune disease that initially presents in the form of intraoral lesions that extend to other mucous membranes and skin. The etiology of pemphigus vulgaris is still unknown, although the disease has attracted considerable interest.Pemphigus vulgaris is an autoimmune, intraepithelial, blistering disease affecting the skin and mucous membranes. 1 The incidence rate of pemphigus is 1–16 cases per year per million people. 2 Pemphigus vulgaris is associated with the binding of IgG autoantibodies to desmoglein 3, a transmembrane glycoprotein adhesion molecule present on desmosomes resulting in loss of intercellular adhesion and separation of cells called as acantholysis in lower layers of stratum spinosum.    

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