Open Access Lipidomics

Lipids generate membranes in biological systems, and they play a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipids expressed in cell membranes and organelles as well as in tissues at the compositional level, whose lipid distribution remains unclear. Glycerophospholipids are the most abundant lipid tissue, they share a similar distribution of tissue but differentiate between tissues in particular. Sphingolipids are more concentrated in the renal cortex, and sterol lipids can mainly be found in both the liver and kidneys. Both visceral and subcutaneous types of white adipose tissue are rich in glycerolipids but differ the amount. Acylcarnitines are mainly found in the skeletal muscle, gluteus and soleus, while the heart has higher ubiquinone levels than other tissues. SP is formed by saturated and monounsaturated fatty acids that give sphingolipids a geometry that, together with cholesterol, contributes to the formation of lipid microdomain that is likely to affect the biophysical properties of the membrane such as microviscosity in a tissue-specific manner.