ISSN: 2048-9145

Pharmaceutical Bioprocessing

New Finding In Structure-Based Drug Design

 Structure-based design begins with the assumption that by binding specifically to a target macromolecular receptor, usually protein, a drug molecule exercises its biological activity. Consequently, biological activity of this target protein is modulated, and this step preferably contributes to the cure for disease. A complete complementarity of structure and chemistry between ligand and receptor is a prerequisite for effective and selective target binding. The technique of "structure-based design" involves a variety of methods for discovering and optimizing small molecule ligands that fit precisely into a depression on a protein surface where the actual function of the protein is usually performed.  

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