Mutagenesis Journals
Mutagenesis may be a process by which the genetic
information of an organism is modified , leading to a mutation. It may occur spontaneously in nature, or as a results of exposure to mutagens. It can also be achieved experimentally using laboratory procedures. In nature mutagenesis can cause
cancer and various heritable diseases, but it's also a drive of evolution. J. M. Robson in the first half of the 20th century .An important group of enzymes involved within the generation of mutagenic metabolites is cytochrome P450. Other enzymes which will also produce mutagenic metabolites include glutathione S-transferase and microsomal epoxide hydrolase. Mutagens that aren't mutagenic by themselves but require biological activation are called promutagens. Mammalian nuclear DNA may sustain quite 60,000 damage episodes per cell per day, as listed with references in DNA damage (naturally occurring). If left uncorrected, these adducts, after misreplication past the damaged sites, can produce to mutations. In nature, the
mutations that arise could also be beneficial or deleterious—this is that the drive of evolution. An organism may acquire new traits through mutation , but mutation can also end in impaired function of the genes, and in severe cases, cause the death of the organism. Mutation is additionally a serious source for acquisition of resistance to antibiotics in bacteria and possibly to antifungal agents in yeasts.
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