Stem Cell Research and Regenerative Medicine

MSC Transplantation

 Mesenchymal stromal cells (MSCs) are a subpopulation of multipotent cells originally identified in the bone marrow. MSCs are characterized by their fibroblast-like appearance, colony forming unit capacity, and their rapid adherence to tissue culture plastic. Although MSCs are relatively easy to isolate, culture, and expand (from a number of tissues), the lack of a unique marker to identify MSCs has impacted the advancement of this research field as difficulties arise in comparing data using different MSC populations. In 2006, the International Society for Cellular Therapy proposed a set of phenotypic and functional criteria to define MSCs, however, the discovery of new markers that specifically identify MSCs are eagerly awaited. MSCs have the capacity to differentiate into adipocytes, chondrocytes, and osteoblasts in vitro and in vivo . Based on the differentiation potential of MSCs, initially studies focused on the regenerative capacity of these cells ; however, over time, it became clear that MSCs mediated their effects predominantly through the production of trophic factors . Indeed, some of these trophic factors facilitate MSC modulation of immune responses.  

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