ISSN: 2041-6792

Clinical Investigation

Lupus Nephritis Journals

 The etiology of the disease is not well-known. Some cases are related to hereditary deficiencies of the complement and others can be induced by drugs. The development of autoimmunity has been attributed to inadequate elimination of autoreactive lymphocytes. Some intrarenal antigens, like components of the extracellular matrix and glycoproteins, can serve as target of the autoimmune attack. In addition, antiphospholipid antibodies can promote thrombosis or vascular injury. In lesions with membranous features there is cytotoxic injury of podocytes by antibodies and complement. The diagnosis requires correlation of clinical and laboratory findings; there is not an only test or clinical finding that allows to confirm it and only a renal biopsy does not permit to make the diagnosis

High Impact List of Articles

Relevant Topics in Clinical