Annals of Clinical Trials and Vaccines Research

HIV Vaccination Scholarly Journal

 A vaccine—also called a “shot” or “immunization”—is a substance that teaches your body's immune system to recognize and defend against harmful viruses or bacteria. Vaccines given before you get infected are called “preventive vaccines” or “prophylactic vaccines,” and you get them while you're healthy. This allows your body to set up defenses against those dangers ahead of time. That way, you will not get sick if you're exposed to diseases later. Preventive vaccines are widely used to prevent diseases like polio, chicken pox, measles, mumps, rubella, influenza (flu), hepatitis A and B, and human papillomavirus (HPV). There is currently no vaccine available which will prevent HIV infection or treat those that have it. However, scientists are working to develop one. NIH is investing in multiple approaches to stop HIV, including a secure and effective preventive HIV vaccine. These research efforts include two late-stage, multinational vaccine clinical trials called Imbokodo and Mosaico. Other NIH-supported research aims to deliver additional HIV prevention options that are safe, effective, and desirable to diverse populations and scalable worldwide to help end the global pandemic. Today, more people living with HIV than ever before have access to life-saving treatment with HIV medicines (called antiretroviral therapy or ART), which is sweet for his or her health.

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