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Epigenome Review Articles

 The epigenome of male and feminine gametes at the time of syngamy may be a product of an extended, complex reprogramming process starting with the naïve epigenome of the primordial germ cells (PGCs). The molecular constituents of the mature gametes and zygote and their spacing, at this point of transcriptional silence, regulate completion of meiosis and activation of the embryonic genome, and that they can also contribute to the morphogenesis of the first pre implantation embryo. The vegetative cell to a state compatible with development. Yet, the stochastic nature of this reprogramming, failure may be a more likely outcome. Understanding the establishment of the gametic epigenomes and therefore remodeling into the zygotic epigenome may be a understanding totipotency and the molecular basis of mammalian development.

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