Drug Toxicity Impact Factor
Drug toxicity may be a major limiting factor for the usefulness of widely used agents. The incidence of
adverse drug reactions in HIV-infected patients varies with the type of drug and dosage used, the drug interactions and the stage of HIV infection. Toxicity refers to how toxic a substance can be. Drug toxicity occurs in the context of
pharmacology when a person has accumulated too much of a drug in his bloodstream leading to adverse effects on the body. Assessment of toxicity / safety of
drugs is essential for the discovery and development of drugs. Drug-induced toxicity in the liver, heart, kidney and
brain currently accounts for over 70% of the attrition and withdrawal of drugs. Drug toxicity refers to the level of damage an organism may suffer from a compound. A drug's toxic effects are dose-dependent and can affect a whole system like in the CNS, or a specific organ like the liver. Drug toxicity typically occurs at concentrations that exceed a drug's therapeutic efficacy; but both toxic and therapeutic effects can occur. It can be assessed at the physiological or behavioral level. Behaviorally, drug toxicity can be exhibited in a variety of ways, e.g. locomotive activity decreases, loss of motor coordination, cognitive impairment. Examples of physiological effects include tissue lesions, neuronal death and perturbed hormonal cycles.
High Impact List of Articles
Relevant Topics in Medical