Drug Safety Scholarly Journal

 The main goals of drug enlargement are effectiveness and safety. Because all drugs can damage as well as help, safety is relative. The alteration between the usual effective dose and the dose that causes severe or life-threatening side effects is called the margin of safety. A wide margin of safety is anticipated, but when treating a risky condition or when there are no other options, a narrow margin of safety often must be accepted. If a drug's usual operative dose is also toxic, doctors do not use the drug unless the situation is serious and there is no safer substitute. The most useful drugs are active and, for the most part, safe. Penicillin is such a drug.  

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