Drug Metabolism Scientific Journals
Drug metabolism is that the metabolic breakdown of medicine by living organisms, usually through specialized enzymatic systems. Which are compounds foreign to an organism's normal biochemistry, like any drug or poison. These pathways are a sort of
biotransformation present altogether major groups of organisms and are considered to be of ancient origin. Drug metabolism is divided into three phases. In phase, I, enzymes like cytochrome P450 oxidases introduce reactive or polar groups into xenobiotics. These modified compounds are then conjugated to polar compounds in phase II reactions. These reactions are catalysed by transferase enzymes like glutathione S-transferases. Finally, in phase III clinical trial, the conjugated
xenobiotics could also be further processed, before being recognised by efflux transporters and pumped out of cells. The metabolism of pharmaceutical
drugs is a crucial aspect of
pharmacology and medicine. For example, the rate of metabolism determines the duration and intensity of a drug's pharmacologic action. Drug metabolism also affects multidrug resistance in infectious diseases and in
chemotherapy for cancer, and therefore the actions of some
drugs as substrates or inhibitors of enzymes involved in xenobiotic metabolism are a standard reason for hazardous drug interactions. Drug metabolism is divided into three phases and also we can differ them.
High Impact List of Articles
Relevant Topics in Clinical