Drug Disposition Open Access Journal
The absorption, distribution, metabolism, and
elimination (ADME) of drugs can be influenced by the physiological and biochemical changes that occur due to various diseases. These changes can have dramatic influence on the exposure of drugs and lead to drug toxicity or lack of drug efficacy. Results indicated that the metabolism of drugs in diabetic patients was affected by factors such as age, sex, effectiveness of treatment, and type of diabetes. On the other hand, in patients with untreated type 1 diabetes the excretion rate was higher when compared with the patients treated with insulin. Pharmacodynamics (PD) is the study of the biochemical and physiologic effects of
drugs (especially pharmaceutical drugs). The effects can include those manifested within animals (including humans), microorganisms, or combinations of organisms (for example, infection). Four processes encompass the pharmacokinetics of a medication. They are absorption, distribution, metabolism, and excretion. Each of these processes is influenced by the route of
administration and the functioning of body organs. Pharmacodynamic mechanisms. Pharmacodynamic mechanisms regulate the effects of
drugs on the human body. As noted earlier, drug-receptor binding results in multiple, complex chemical interactions. The site on the receptor at which a drug binds is called its binding site.
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