Stem Cell Research and Regenerative Medicine

Bone Marrow Review Journals

 Ischemic stroke is one of the world's leading causes of death and injury but few successful therapeutic treatments actually exist for it. Additionally, cell-based therapy offered encouraging hope that tissue regeneration and functional recovery after stroke could be increased. Bone marrow stromal cells (BMSCs) can easily be collected without ethical or immunological issues from patients themselves, and can proliferate in vitro massively. It can promote neurogenesis and angiogenesis in ischemic brain after transplantation.   However, the low survival of the transplanted cells in brain lesion limits cell therapy. Studies have confirmed that a great number of transplanted cells died in ischemic brain due to hypoxia, oxidative stress, inflammatory mediators and trophic factor deficiency. Thus, therapies that can boost the viability of stem cells in the dangerous ischemic tissue are essential to recognize.

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