Angiogenesis is the physiological process through which new blood vessels, formed in the earlier stage of vasculogenesis, form from pre-existing vessels. Angiogenesis continues the growth of the vasculature by sprouting and splitting processes. Vasculogenesis is the embryonic formation of endothelial cells from the precursors of mesoderm cells and from neovascularization, though discussion is not always precise. Vasculogenesis forms the first vessels in the developing embryo, during which angiogenesis is responsible for much, if not all, of the formation of the blood vessels during development and in disease. Angiogenesis is a natural and essential process in growth and development, in wound healing and in granulation tissue formation. It is, however, also a crucial step in transforming tumors from a benign to a malignant state , leading to the use of angiogenesis inhibitors in cancer care.

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