ISSN: 2044-9038 (Print) 2044-9046 (Electronic)

Clinical Practice

Biomechanics Online Journals

Biomechanics is considered one of the core disciplines to understand principles of physiology and pathophysiology in the human. Decades of biomechanics research revealed many primary principles regulating growth, tissue formation, organism morphogenesis, and tissue regeneration. Not surprisingly, biomechanics is one of the core sciences used to understand how dynamic loading in the central nervous system (CNS) causes injury. This key transition from physiology to pathophysiology is especially important, as early pathophysiologic changes to the CNS can strongly influence cellular decisions to survive, reintegrate, and repair the injured CNS. Compared to nearly every other application of biomechanics and human body, biomechanics of traumatic loading has three unique components. First, the mechanical event is nearly always considered as a single event, rather than a series of cyclical loadings that are applied to organ/tissue/cellular preparations. In other areas of biomechanics, cyclical loading of tissue/cellular components is critical in defining the homeostatic response and the adaptation of this response during disease. In contrast, the brain and spinal cord are considered “mechanically protected” organs and do not have a clear constant level of mechanical stimulation. Second, traumatic loading is probably the fastest event studied in biomechanics, especially considering the very recent work on blast injury biomechanics.    

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