ISSN: 2048-9145

Pharmaceutical Bioprocessing

Bioengineering Scientific Journals

The bioengineers, cell biologists and clinicians face challenges towards further development of ideal wound dressing template with ongoing interaction and collaborations. Stem cell therapy may be a new milestone and strategy with the characteristics of self-renewal and multilineage differentiation. Identification and site of stem cells in skin have already been achieved and ongoing research proved the potential contribution of stem cells within the reconstitution of skin at the wound site. Epidermal keratinocytes have a poor regenerative capacity which can be overcome by utilising self-renewing keratinocyte stem cells. In the next decade, somatic cell therapy are going to be a breakthrough in skin tissue engineering to get skin substitutes which will completely mimic structures and performance of the native skin Collaboration between bioengineers and clinicians has yielded three-dimensional constructs tailored to deal with specific animal tissue contour demands. Several materials like Matrigel®, alginate, and collagen sponges are ideal for adipose and endothelial tissue engineering but lack strong structural support. Poly(ethylene glycol)-based hydrogels have demonstrated the ability to promote adipogenic differentiation in vivo whereas apatite-coated polylactic-co-glycolic acid scaffolds have been used in concert with ASCs to treat calvarial (bony) defects in mice. It is theorized that the spacing and orientation that these engineered scaffolds provide are a crucial cue to the stem cells.    

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